Quinine sulfate dihydrate

Research use only, not for human use.

Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent.

Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.

Quinine sulfate hydrate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line.Quinine sulfate hydrate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line.Cell Proliferation Assay Cell Line:Human hepatocarcinoma cell line(HepG2)Concentration:150 μM Incubation Time:30 min Result:Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.

Quinine sulfate hydrate (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice.Quinine sulfate hydrate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats.Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g) Dosage:12 mg/kg, 15 mg/kg Administration:Oral gavage; every week; 16 weeks Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.

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Cell Cycle/DNA Damage

Potassium Channel

Others | Potassium Channel

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6119-70-6

818.97

C40H58N4O12S

>98% (HPLC)

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O.O.OS(O)(=O)=O.[H][C@@]12CCN(C[C@@H]1C=C)[C@@]([H])(C2)[C@H](O)c1ccnc2ccc(OC)cc12.[H][C@@]12CCN(C[C@@H]1C=C)[C@@]([H])(C2)[C@H](O)c1ccnc2ccc(OC)cc12

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(-20℃)

With Ice Pack

≥ 2 years